Antibiotics Mock Test Questions for Staff Nurse Exam – Part 4 (Q01–25)
Tags: antibiotics mcq, staff nurse exam questions, medical entrance, pharmacology questions, nursing competitive exam, antibiotics mock test
Description: Practice 25 important multiple choice questions on antibiotics for Staff Nurse Exam preparation. Includes questions with Show Answer button and correct answers in green. Useful for AIIMS, ESIC, HPSSC, NRHM and nursing exams.
01. The most important mechanism by which tetracycline antibiotics exert antimicrobial action is:
(A) They chelate Ca2+ ions and alter permeability of bacterial cell membrane
(B) They bind to 30S ribosomes and inhibit bacterial protein synthesis
(C) They bind to 50S ribosomes and interfere with translocation of the growing peptide chain in the bacteria
(D) They interfere with DNA mediated RNA synthesis in bacteria
02. Select the most potent tetracycline antibiotic:
(A) Demeclocycline
(B) Methacycline
(C) Minocycline
(D) Doxycycline
03. An 8-year-old child presented with brownish discoloured and deformed anterior teeth. History of having received an antibiotic about 4 years earlier was obtained. Which antibiotic could be responsible for the condition?
(A) Chloramphenicol
(B) Tetracycline
(C) Erythromycin
(D) Gentamicin
04. The most suitable tetracycline for use in a patient with impaired renal function is:
(A) Chlortetracycline
(B) Demeclocycline
(C) Oxytetracycline
(D) Doxycycline
05. Compared to older tetracyclines, doxycycline produces a lower incidence of superinfection diarrhoea because:
(A) It is completely absorbed in the small intestines so that drug concentration in the colonic contents is low
(B) It is inactivated by the gut microflora
(C) It is not active against the microbes of the normal gut flora
(D) It is a potent tetracycline and inhibits the superinfection causing microbes as well
06. Tetracyclines are still the first choice drugs for the following disease:
(A) Granuloma inguinale
(B) Chancroid
(C) Syphilis
(D) Gonorrhoea in patients allergic to penicillin
07. Chloramphenicol is more active than tetracyclines against:
(A) Bacteroides fragilis
(B) Treponema pallidum
(C) Streptococci
(D) Staphylococci
08. Which out of the following antibiotics penetrates blood-CSF barrier the best:
(A) Erythromycin
(B) Gentamicin
(C) Tetracycline
(D) Chloramphenicol
09. The most important mechanism by which gram negative bacilli acquire chloramphenicol resistance is:
(A) Decreased permeability into the bacterial cell
(B) Acquisition of a plasmid encoded for chloramphenicol acetyl transferase
(C) Lowered affinity of the bacterial ribosome for chloramphenicol
(D) Switching over from ribosomal to mitochondrial protein synthesis
10. What is the most important reason for restricted clinical use of chloramphenicol?
(A) Its narrow spectrum of activity
(B) Emergence of chloramphenicol resistance
(C) Its potential to cause bone marrow depression
(D) Its potential to cause superinfections
11. Aminoglycoside antibiotics have the following common property:
(A) They are primarily active against gram-negative bacilli
(B) They are more active in acidic medium
(C) They readily enter cells and are distributed in total body water
(D) They are nearly completely metabolized in liver
12. Which aminoglycoside antibiotic causes more hearing loss than vestibular disturbance as toxic effect?
(A) Streptomycin
(B) Gentamicin
(C) Kanamycin
(D) Sisomicin
13. Which of the following drugs has demonstrated in vitro activity against Mycobacterium avium-intracellular (MAI)?
(A) Vancomycin
(B) Clarithromycin
(C) Erythromycin base
(D) Troleandomycin
(E) Erythromycin estolate
14. The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is:
(A) Plasmid mediated acquisition of aminoglycoside conjugating enzyme
(B) Mutational acquisition of aminoglycoside hydrolyzing enzyme
(C) Mutation reducing affinity of ribosomal protein for the antibiotic
(D) Mutational loss of porin channels
15. Which toxic effect of aminoglycoside antibiotics is most irreversible in nature?
(A) Vestibular damage
(B) Hearing loss
(C) Neuromuscular blockade
(D) Kidney damage
16. Streptomycin sulfate is not absorbed orally because it is:
(A) Degraded by gastrointestinal enzymes
(B) Destroyed by gastric acid
(C) Highly ionized at a wide range of pH values
(D) Insoluble in water
17. The aminoglycoside antibiotic which is distinguished by its resistance to bacterial aminoglycoside inactivating enzymes is:
(A) Kanamycin
(B) Sisomicin
(C) Amikacin
(D) Tobramycin
18. An aminoglycoside antibiotic should not be used concurrently with the following drug:
(A) Ampicillin
(B) Vancomycin
(C) Ciprofloxacin
(D) Rifampin
19. All of the following statements regarding pentamidine isethionate are true except:
(A) It is indicated for treatment or prophylaxis of infection due to Pneumocystis carinii
(B) It may be administered intramuscularly, intravenously or by inhalation
(C) It has no clinically significant effect on serum glucose
(D) It is effective in the treatment of leishmaniasis
20. Prolonged oral therapy with the following antibiotic can damage intestinal villi resulting in steatorrhea and loose motions:
(A) Ampicillin
(B) Tetracycline
(C) Neomycin
(D) Nystatin
21. Hepatitis with cholestatic jaundice occurs most frequently as an adverse reaction to the following preparation of erythromycin:
(A) Erythromycin base
(B) Erythromycin stearate
(C) Erythromycin estolate
(D) Erythromycin ethylsuccinate
22. The following antibiotic is a first line drug for treatment of Mycobacterium avium complex infection in AIDS patients:
(A) Clindamycin
(B) Clarithromycin
(C) Roxithromycin
(D) Erythromycin
23. Roxithromycin has the following advantages over erythromycin except:
(A) It is more effective in whooping cough
(B) It causes less gastric irritation
(C) It has longer plasma half-life
(D) It is unlikely to precipitate theophylline toxicity
24. Highest incidence of antibiotic-associated pseudomembranous enterocolitis has been noted with the use of:
(A) Ampicillin
(B) Chloramphenicol
(C) Vancomycin
(D) Clindamycin
25. The drug of choice for treatment of methicillin-resistant Staphylococcus aureus infection is:
(A) Cloxacillin
(B) Vancomycin
(C) Erythromycin
(D) Amikacin
Note: These questions are prepared for practice only. For latest syllabus and exam patterns, refer to official notifications.
Follow Us: Like our Facebook Page for daily mock tests and updates.
%20Recruitment%202025.png)
0 Comments